2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140066
    endo-BCN-PEG12-acid
    endo-BCN-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG12-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG12-acid
  • HY-140869
    N-(Azido-PEG3)-N-bis(PEG4-Boc) 2353409-58-0
    N-(Azido-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG4-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-bis(PEG4-Boc)
  • HY-143832
    Cbz-PEG5-Br 2710803-69-1
    Cbz-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-PEG5-Br
  • HY-134695
    5-(Biotinamido)pentylazide 1349190-76-6
    5-Biotinamidopentylazide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-(Biotinamido)pentylazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5-(Biotinamido)pentylazide
  • HY-130855
    Mal-amido-PEG7-acid 2112731-42-5
    Mal-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG7-acid
  • HY-141207
    Hydroxy-PEG20-Boc
    Hydroxy-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG20-Boc
  • HY-140363
    m-PEG3-OMs 74654-05-0
    m-PEG3-OMs is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-OMs
  • HY-140376
    Boc-NH-PEG7-Tos 1292268-14-4
    Boc-NH-PEG7-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG7-Tos
  • HY-138340
    THP-PEG8-Boc
    THP-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG8-Boc
  • HY-140483
    Acid-C1-PEG5-Boc 2304558-22-1
    Acid-C1-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-C1-PEG5-Boc
  • HY-130204
    m-PEG8-azide 869718-80-9
    m-PEG8-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG8-azide
  • HY-130473
    Tos-PEG4-CH2COOH 2028284-73-1
    Tos-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG4-CH2COOH
  • HY-138504
    Bis-PEG2-Boc 1611468-28-0
    Bis-PEG2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG2-Boc
  • HY-133189
    Bis-propargyl-PEG9 1351373-47-1
    Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands. Bis-propargyl-PEG9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG9
  • HY-140936
    Biotin-PEG6-Boc 1352814-07-3
    Biotin-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG6-Boc
  • HY-138520
    5-[Boc(methyl)amino]pentanal 1620280-47-8
    5-[Boc(methyl)amino]pentanal is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    5-[Boc(methyl)amino]pentanal
  • HY-141124
    NHS-PEG4-(m-PEG4)3-ester 1333154-70-3
    NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NHS-PEG4-(m-PEG4)3-ester
  • HY-134717
    Benzyl-PEG24-azide
    Benzyl-PEG24-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG24-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG24-azide
  • HY-141098
    Acid-PEG25-NHS ester 2563872-17-1
    Acid-PEG25-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG25-NHS ester
  • HY-140713
    HO-PEG-amine (MW 1000)
    HO-PEG-amine (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG-amine (MW 1000)
PROTAC Linkers Isoform Comparison

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